Advanced Search and Structure Search

Clear Board Search Bitte warten...
Advanced Search and Structure Search
    High Level Building Blocks for Drug Discovery

      Gute Chemie connects.

      Heterocycles from Bellen.

      abcr has an exclusive partnership with Bellen for the distribution of catalog compound in Europe. A great opportunity to bundle building blocks, catalysts and reagents in the same order. abcr GmbH is responsible for small quantities of the Bellen productlines Indazole, Quinazoline, Isoquinoline, Quinoline, Pyrozole, Pyridine, Piperidine, Aza-Indazole from gram units up to kg units.

      Heterocycles from Bellen


      This novel building blocks can be used as hinge binders required for kinase ATP-pocket inhibitors. These hinge binders were designed carefully so that they can form one to three hydrogen bonds to the hinge. They contain one to multiple functional groups at various positions that can be derivatized sequentially.

      Kinase inhibitors are a clinically important family of prescription drugs that belong to the class of so called targeted therapy, for the treatment of cancer and more recently in the immunology area for the treatment of arthritis.

      Phenyl Isostere from Bellen

      Phenyl Isostere

      Facilitate your SAR studies by switching one of your phenyl group to the bicyclo[1.1.1]pentane. Bicyclo[1.1.1]pentane or 2-F-bicyclo[1.1.1]pentane is a phenyl isostere. It offers the following benefits for this isostere replacement: Maintain the same molecular weight - Increase the sp³ character / reduce
      the flatness of the final product - Increase solubility and permeability of the final product - Reduce the clogp and clog D - Increase LELP, LE

      (References: J. Med. Chem., 2012, 55, 3414-3424; ChemMedChem 2015, 10, 461-469)

      abcr exclusive distribution from Bellen catalogue compounds in Europe

      • Small quantities in gram scale available from abcr stock
      • Bulk quantities on request
      • Orders placed directly via webshop, shipments sent to your address without intermediate storage
      • Short delivery times, typically within 1 - 2 days, ex works, shipped with high delivery reliability
      • Payment possible by bank transfer and credit card (Visa, Master Card)
      • Technical Service will continue to be at your disposal

      Novel Building Blocks for Drug Discovery.

      With abcr, you have access to over 260,000 products from the organic, organometallic and inorganic specialtiy chemical areas. Here you can find some highlighted compounds to use for drug discovery in the medicinal chemistry.

      Product category: Indazole
      Product category: Quinazoline
      Product category: Isoquinoline
      Product category: Quinoline
      Product category: Bioisostere